ES009: A Potential Best-in-Class Antibody Targeting LILRB2
ES009 is a potential best-in-class monoclonal antibody targeting LILRB2 designed to reprogram inhibitory myeloid cells to create an immune favorable TME. LILRB2 is an inhibitory receptor that suppresses myeloid cell activation. Blocking LILRB2 reverses immunosuppression by reprograming tumor-associated macrophages (TAMs) from M2 (pro-tumor) to M1 (anti-tumor) phenotype, leading to immune responses including myeloid cell activation and pro-inflammatory cytokine release.
In preclinical studies, ES009 demonstrated potent ligand blockade and effective reprogramming of TAMs from M2 to M1, leading to pro-inflammatory cytokine release from macrophages as well as T cell proliferation and activation.
Mechanism of Action