ES102: Potential Best-in-Class OX40 Agonist Antibody
OX40 (CD134) is a member of the tumor necrosis factor (TNF) receptor family and is an important co-stimulator of T cell responses. Three OX40 molecules bind to the trivalent OX40 ligand (OX40L), activating downstream NF-κB, PI3K, and AKT pathways, which leads to an increased cytokine production. The activation of OX40 enhances T cell expansion, differentiation, and the generation of memory T cells.
ES102 is a hexavalent OX40 agonist that consists of six OX40 single-domain antibody structures, which facilitates the clustering of OX40. ES102 induces a stronger downstream signaling than bivalent OX40 antibodies and trivalent endogenous OX40L.