Elpiscience is dedicated to transforming cancer treatment by developing innovative immunotherapies that turn “cold” tumors “hot”. By unlocking differentiated biology, we aim to enhance crosstalk between innate and adaptive immunity, harnessing the full potential of the immune system to fight cancer .

Cancer Immunotherapy

Harnessing the immune system to fight cancer has been a scientific pursuit for over a century. In recent years, immune checkpoint inhibitors have revolutionized cancer treatment, offering patients powerful new options.

However, two key challenges remain: identifying novel biological pathways with clinical relevance and developing preclinical models that reliably predict therapeutic success.

At Elpiscience, we tackle these challenges by uncovering unique biological insights that can effectively activate the immune system. Our experienced research and development teams, supported by world-renowned scientists, are committed to advancing next-generation immunotherapies.

Our Systemic Dual Approach

To overcome the immune system’s failure to fight cancer, Elpiscience is committed to revolutionizing cancer treatment by adopting a holistic and systematic approach to immunotherapy. Since multiple mechanisms contribute to immune evasion, we focus on two key strategies to restore immune function and drive robust anti-tumor responses.

Removing Immune Suppressive Factors in the Tumor Microenvironment (TME)

Tumors create an immunosuppressive microenvironment that actively inhibits immune responses. Various immune and non-immune cells within the TME secrete factors that trigger inhibitory signals, forming a significant barrier to effective immunotherapy. Elpiscience develops targeted therapies to neutralize these suppressive mechanisms, enhancing the immune system’s ability to fight cancer.

Reinvigorating Exhausted T Cells

In cancer patients, prolonged antigen exposure leads to T cell exhaustion, reducing their ability to attack tumors. Restoring T cell function is essential for a sustained and potent immune response. Elpiscience designs therapies that modulate costimulatory and inhibitory signaling pathways, revitalizing T cells to generate stronger and more durable anti-tumor effects.