Elpiscience aims to transform cancer treatment by developing immunotherapies to turn “cold” tumors “hot.” We strive to find differentiated biology to enable effective crosstalk between innate immunity and adaptive immunity, harnessing the full potential of the immune system to fight cancer.
Elpiscience leverages our deep understanding of tumor biology and mechanisms of action to translate target biology for challenging pathways, develop biomarkers and strategically select indications and patients for clinical studies. We apply cutting-edge technologies including gene editing for target screening, single cell sequencing and advanced bioinformatics with over 1,000 tumor organoid model collections that mimic the complex interaction between the human immune system and tumor microenvironment.
BiME® platform is designed to bring activated macrophages to tumor cells by simultaneously binding to inhibitory receptors such as SIRPα on the macrophage and a specific antigen on tumor cells. The SIRPα antibody blocks the “don’t-eat-me” signal, while the TAA antibody provides an “eat-me” signal through Fc receptor engagement. Together, they lead to strong activation of phagocytosis and directly kill tumor cells.
Acebody™ is a proprietary H - L interchain disulfide bond engineering platform. It is designed to solve the challenging issues for IgG-like BsAb by adopting 2 pairs of alternative interchain disulfide bond to increase cognate H - L pairing rate and stability of the target antibody. It ensures simple production workflow and can retain binding and functional properties of parental mAb.
ElpiSource is a human naïve Fab antibody library displayed on yeast cell surface whose diversity exceeds 1010. The library reduces the time for "target to sequence" delivery to 2-3 months by skipping the process for animal immunization and humanization. It also avoids the potential risk of affinity change derived from humanization and format conversion. More unique sequences can be generated. The library contains a semi-synthetic sub-library that covers main human productive heavy chain germline frameworks and a completely naïve sub-library that captures natural diversity.
